Prediction of the response to chemoradiation and prognosis in oesophageal squamous cancer

Background: The sensitivity of cancer cells to chemotherapy and radiation therapy depends on various biological properties. This study investigated the expression of p53, CDC25B and metallothionein (MT), and evaluated their clinical significance in chemoradiation therapy (CRT) for oesophageal squamo...

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Bibliographic Details
Published in:British journal of surgery 2002-05, Vol.89 (5), p.597-603
Main Authors: Kishi, K., Doki, Y., Miyata, H., Yano, M., Yasuda, T., Monden, M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - radiotherapy
cdc25 Phosphatases - metabolism
Cell Cycle Proteins - metabolism
Cisplatin - administration & dosage
Esophageal Neoplasms - drug therapy
Esophageal Neoplasms - metabolism
Esophageal Neoplasms - radiotherapy
Esophagus
Female
Fluorouracil - administration & dosage
Gastroenterology. Liver. Pancreas. Abdomen
Genes, p53
Humans
Immunohistochemistry
Infusions, Intravenous
Male
Medical sciences
Metallothionein - metabolism
Middle Aged
Survival Analysis
Treatment Outcome
Tumors
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Summary:Background: The sensitivity of cancer cells to chemotherapy and radiation therapy depends on various biological properties. This study investigated the expression of p53, CDC25B and metallothionein (MT), and evaluated their clinical significance in chemoradiation therapy (CRT) for oesophageal squamous cell carcinoma. Methods: The expression of p53, CDC25B and MT was evaluated by immunohistochemistry using biopsy specimens taken before CRT for 77 patients with oesophageal squamous cell carcinoma, and correlated with the pathological effects of CRT and survival. Results: p53‐positive tumours and MT‐positive tumours had a poor response to CRT, whereas tumours with strong CDC25B expression were associated with a good response. When each patient was scored for the presence of the three biological factors, there was a strong correlation between the sensitivity score and the pathological effect of CRT (P < 0·001), and a (non‐significant) difference in the 5‐year survival rate between patients with a high score and those with a low score (67 versus 34 per cent respectively; P = 0·12). Conclusion: The combined evaluation of p53, CDC25B and MT may help to identify patients with advanced oesophageal squamous cell carcinoma who will benefit from preoperative CRT. © 2002 British Journal of Surgery Society Ltd
ISSN:0007-1323
1365-2168
DOI:10.1046/j.1365-2168.2002.02057.x