Expression of FoxC, FoxF, FoxL1, and FoxQ1 genes in the dogfish Scyliorhinus canicula defines ancient and derived roles for fox genes in vertebrate development

In the human genome, members of the FoxC, FoxF, FoxL1, and FoxQ1 gene families are found in two paralagous clusters. Here we characterize all four gene families in the dogfish Scyliorhinus canicula, a member of the cartilaginous fish lineage that diverged before the radiation of osteichthyan vertebr...

Full description

Saved in:
Bibliographic Details
Published in:Developmental dynamics 2008-06, Vol.237 (6), p.1590-1603
Main Authors: Wotton, Karl R., Mazet, Françoise, Shimeld, Sebastian M.
Format: Article
Language:English
Subjects:
Animals
Catshark
Cell Lineage
Chordata
Dogfish
Endoderm
Evolution, Molecular
forkhead
Forkhead Transcription Factors - biosynthesis
Forkhead Transcription Factors - physiology
FoxC
FoxF
FoxL
FoxQ
gene cluster
Gene Expression Regulation, Developmental
In Situ Hybridization
Marine
Mesoderm
Multigene Family
Protein Structure, Tertiary
Scyliorhinus canicula
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the human genome, members of the FoxC, FoxF, FoxL1, and FoxQ1 gene families are found in two paralagous clusters. Here we characterize all four gene families in the dogfish Scyliorhinus canicula, a member of the cartilaginous fish lineage that diverged before the radiation of osteichthyan vertebrates. We identify two FoxC genes, two FoxF genes, and single FoxQ1 and FoxL1 genes, demonstrating cluster duplication preceded the radiation of gnathostomes. The expression of all six genes was analyzed by in situ hybridization. The results show conserved expression of FoxL1, FoxF, and FoxC genes in different compartments of the mesoderm and of FoxQ1 in pharyngeal endoderm and its derivatives, confirming these as ancient sites of Fox gene expression, and also illustrate multiple cases of lineage‐specific expression domains. Comparison to invertebrate chordates shows that the majority of conserved vertebrate expression domains mark tissues that are part of the primitive chordate body plan. Developmental Dynamics 237:1590‐1603, 2008. © 2008 Wiley‐Liss, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.21553