Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury

Fractalkine (FKN), also known as neurotactin, is a CX 3C chemokine that exists in both secreted and neuronal membrane-bound forms and is upregulated during brain inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its receptor CX 3CR1 on leukocytes and microglia. W...

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Bibliographic Details
Published in:Journal of neuroimmunology 2002-04, Vol.125 (1), p.59-65
Main Authors: Soriano, Sulpicio G., Amaravadi, Lakshmi S., Wang, Yanming F., Zhou, Hong, Yu, Gary X., Tonra, James R., Fairchild-Huntress, Victoria, Fang, Qing, Dunmore, Judy H., Huszar, Dennis, Pan, Yang
Format: Article
Language:English
Subjects:
Adhesion molecules
Animals
Cerebral ischemia
Chemokine CX3CL1
Chemokines, CX3C - deficiency
Chemokines, CX3C - genetics
Chemokines, CX3C - immunology
Disease Susceptibility - immunology
Fractalkine
Gene Expression - immunology
Infarction, Middle Cerebral Artery - immunology
Infarction, Middle Cerebral Artery - pathology
Ischemic Attack, Transient - immunology
Ischemic Attack, Transient - pathology
Membrane Proteins - deficiency
Membrane Proteins - genetics
Membrane Proteins - immunology
Mice
Mice, Inbred BALB C
Mice, Knockout
Reperfusion Injury - immunology
Reperfusion Injury - pathology
RNA, Messenger - analysis
Stroke
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Summary:Fractalkine (FKN), also known as neurotactin, is a CX 3C chemokine that exists in both secreted and neuronal membrane-bound forms and is upregulated during brain inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its receptor CX 3CR1 on leukocytes and microglia. We generated FKN-deficient mice to study the role of FKN in postischemic brain injury. After transient focal cerebral ischemia, FKN-deficient mice had a 28% reduction in infarction size and lower mortality rate, when compared to wild-type littermates. The findings of this study indicate a possible role for FKN in augmenting postischemic injury and mortality after transient focal cerebral ischemia.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(02)00033-4