Protein Tyrosine Phosphatase 1B: A Potential Leptin Resistance Factor of Obesity

Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphoryl...

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Bibliographic Details
Published in:Developmental Cell 2002-04, Vol.2 (4), p.385-387
Main Authors: Cook, W.S., Unger, R.H.
Format: Article
Language:English
Subjects:
Humans
Leptin - metabolism
Obesity - etiology
Obesity - metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases - metabolism
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Summary:Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.
ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(02)00158-2