Live and Let Die: Nef Functions beyond HIV Replication

The viral Nef protein is important for the progression of the human and simian immunodeficiency virus (HIV/SIV) infection. So far, experimental evidence has suggested that Nef enhances viral replication and infectivity through a combination of different effects. Recent insights, however, indicate th...

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Bibliographic Details
Published in:Immunity 2002-04, Vol.16 (4), p.493-497
Main Authors: Fackler, Oliver T, Baur, Andreas S
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Animals
Apoptosis - immunology
Gene Products, nef - immunology
HIV
HIV - immunology
HIV - physiology
Human immunodeficiency virus
Humans
Kinases
nef Gene Products, Human Immunodeficiency Virus
Nef protein
Receptors, Antigen, T-Cell - immunology
T cell receptors
T-Lymphocytes - immunology
T-Lymphocytes - virology
Virus Replication - immunology
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Summary:The viral Nef protein is important for the progression of the human and simian immunodeficiency virus (HIV/SIV) infection. So far, experimental evidence has suggested that Nef enhances viral replication and infectivity through a combination of different effects. Recent insights, however, indicate that its functions are more complex than previously anticipated. By targeting the T cell receptor, Nef may not only prime viral replication but, more importantly, ensure viral survival through distinct mechanisms of immune evasion and antiapoptosis.
ISSN:1074-7613
1097-4180
DOI:10.1016/S1074-7613(02)00307-2