Reaching a Genetic and Molecular Understanding of Skeletal Development

In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these dif...

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Bibliographic Details
Published in:Developmental Cell 2002-04, Vol.2 (4), p.389-406
Main Authors: Karsenty, Gerard, Wagner, Erwin F.
Format: Article
Language:English
Subjects:
Animals
Bone Development - genetics
Cell Differentiation - genetics
Chondrogenesis - genetics
Space life sciences
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Summary:In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes and presents, in several cases, the genetic cascade leading to cell differentiation.
ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(02)00157-0