Lymphatic Vessels: Pressure- and Flow-dependent Regulatory Reactions

This chapter discusses the current status of knowledge on basic pressure/stretch– and flow/shear–dependent regulatory reactions of contracting lymphangions in lymphatic vessels. The balance of passive and active lymph pumps is discussed; the data on pressure measurements in different lymphatic nets...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2008-05, Vol.1131 (1), p.100-109
Main Author: Gashev, Anatoliy A.
Format: Article
Language:English
Subjects:
Animals
Homeostasis
Humans
lymph flow
lymph pressure
lymph pump
lymphangion
lymphatic vessels
Lymphatic Vessels - physiology
Pressure
Rheology
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Summary:This chapter discusses the current status of knowledge on basic pressure/stretch– and flow/shear–dependent regulatory reactions of contracting lymphangions in lymphatic vessels. The balance of passive and active lymph pumps is discussed; the data on pressure measurements in different lymphatic nets of several species are provided. The characteristics of typical changes in lymphatic contractility to the increases in transmural pressures are described and discussed, as is the role of pre‐existing distension in initiation of lymphatic contractions. The up‐to‐date status of knowledge on flow‐dependent adaptive reactions of contracting lymphangions is provided with detailed characterization of the influences of imposed and contraction‐generated flows on lymphatic contractility. The interaction between extrinsic and intrinsic flows in regulation of lymphatic contractility is considered.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1413.009