Beta-trace protein, cystatin C, beta(2)-microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children

Because of the limitations of serum creatinine as a marker of glomerular filtration rate (GFR) in children, we assessed the diagnostic accuracy of the novel marker beta-trace protein (BTP) in comparison with cystatin C (Cys-C), beta(2)-microglobulin (beta(2)-MG), and creatinine as conventional indic...

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Published in:Clinical chemistry (Baltimore, Md.) Md.), 2002-05, Vol.48 (5), p.729-736
Main Authors: Filler, Guido, Priem, Friedrich, Lepage, Nathalie, Sinha, Pranav, Vollmer, Ilka, Clark, Heather, Keely, Erin, Matzinger, Mary, Akbari, Ayub, Althaus, Harald, Jung, Klaus
Format: Article
Language:English
Subjects:
Adolescent
beta 2-Microglobulin - blood
Biomarkers - blood
Child
Child, Preschool
Creatinine - blood
Cystatin C
Cystatins - blood
Female
Glomerular Filtration Rate
Humans
Infant
Intramolecular Oxidoreductases - blood
Kidney Diseases - diagnosis
Kidney Diseases - physiopathology
Lipocalins
Male
Reference Values
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Summary:Because of the limitations of serum creatinine as a marker of glomerular filtration rate (GFR) in children, we assessed the diagnostic accuracy of the novel marker beta-trace protein (BTP) in comparison with cystatin C (Cys-C), beta(2)-microglobulin (beta(2)-MG), and creatinine as conventional indicators of reduced GFR. We obtained serum samples from 225 children (age range, 0.2-18 years) with various renal pathologies who were referred for nuclear medicine clearance investigations (technetium-diethylenetriamine pentaacetic acid or chromium-EDTA). We measured Cys-C, BTP (nephelometric tests; Dade Behring), beta(2)-MG (Tinaquant; Roche), and creatinine (enzymatic assay; Creatinine-PAP; Roche). Seventy-five children had reduced GFR (90 mL x min(-1) x 1.73 m(-2) comprised the control group with gaussian distributions of BTP and Cys-C concentrations. The upper reference limits (97.5 percentile) were 1.01 mg/L for BTP and 1.20 mg/L for Cys-C. The correlations of nuclear medicine clearance with the reciprocals of BTP, Cys-C, and the Schwartz GFR estimate were significantly higher (r = 0.653, 0.765, and 0.706, respectively; P
ISSN:0009-9147