Compressibility and compactibility of granules produced by wet and dry granulation

The bulk properties, compactibility and compressibility of granules produced by wet and dry granulation were compared applying a rotary tablet press, three different morphological forms of calcium carbonate and two particle sizes of sorbitol. Granules from both granulation methods possessed acceptab...

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Bibliographic Details
Published in:International journal of pharmaceutics 2008-06, Vol.358 (1), p.69-74
Main Authors: Bacher, C., Olsen, P.M., Bertelsen, P., Sonnergaard, J.M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Calcium Carbonate
Compactibility
Compressibility
Drug Compounding
General pharmacology
Granulation
Indicators and Reagents
Medical sciences
Microscopy, Electron, Scanning
Morphology
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Porosity
Povidone - chemistry
Powders - chemistry
Pressure
Roller compaction
Sorbitol - chemistry
Stearic Acids - chemistry
Tablets
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Summary:The bulk properties, compactibility and compressibility of granules produced by wet and dry granulation were compared applying a rotary tablet press, three different morphological forms of calcium carbonate and two particle sizes of sorbitol. Granules from both granulation methods possessed acceptable flow properties; however, the ground (Mikhart) and cubic (Scoralite) calcium carbonate demonstrated better die-filling abilities in the tablet press than the scalenhedral calcium carbonate (Sturcal). The wet processed granules showed in general larger compression properties. This was explained as these granules were mechanical stronger and had a higher initial porosity. In some cases, a large particle surface area of calcium carbonate and sorbitol resulted in a small, insignificant improvement of the consolidation characteristics. A correlation between the compression and compaction characteristics was demonstrated.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2008.02.013