Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty

• Published in: European heart journal 2002-05, Vol.23 (9), p.726-733
• Main Authors: Schnyder, G., Roffi, M., Flammer, Y., Pin, R., Hess, O.M.
• Format: Article
• Language: English
• Subjects: Aged; Angioplasty; Angioplasty, Balloon, Coronary - adverse effects; Biological and medical sciences; Biomarkers - blood; Coronary Angiography; Coronary Restenosis - blood; Coronary Restenosis - etiology; Coronary Restenosis - mortality; Coronary Stenosis - complications; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - therapy; Coronary Vessels - surgery; death; Diseases of the cardiovascular system; Endpoint Determination; Female; Follow-Up Studies; homocysteine; Homocysteine - blood; Humans; Incidence; Male; Medical sciences; Middle Aged; myocardial infarction; Postoperative Complications - blood; Postoperative Complications - etiology; Postoperative Complications - mortality; Prospective Studies; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Recurrence; restenosis; Severity of Illness Index; Statistics as Topic; Survival Analysis; Treatment Outcome
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1053/euhj.2001.2962

Aims Restenosis after percutaneous coronary angioplasty remains an important limitation of this procedure. This study evaluates whether elevated total plasma homocysteine levels contribute to the development of restenosis after coronary angioplasty. Methods and Results Two hundred and five patients were recruited after successful angioplasty of at least one coronary stenosis (≥50%). End-points were restenosis (≥50%) and a composite of major adverse cardiac events. Of the 205 patients, 183 (89·3%) underwent 6 months angiographic follow-up. Patients with restenosis had significantly higher homocysteine levels than those without (10·9± 3·9μmol.l−1 vs 9·3±3·8μmol.l−1, P