Animal model pharmacokinetics and pharmacodynamics: a critical review

Animals have been extensively used in the evaluation of antimicrobials. The value of animals in the pharmacokinetic and pharmacodynamic characterization of antimicrobials is critically reviewed. Animal studies have demonstrated that the pharmacokinetic/pharmacodynamic (PK/PD) target determining effi...

Full description

Saved in:
Bibliographic Details
Published in:International journal of antimicrobial agents 2002-04, Vol.19 (4), p.261-268
Main Authors: Andes, D., Craig, W.A.
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - pharmacokinetics
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobials
Bacterial Infections - drug therapy
Biological and medical sciences
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical - methods
General pharmacology
Humans
Medical sciences
Microbial Sensitivity Tests
Models, Animal
Pathogens
Pharmacokinetic/pharmacodynamic
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Animals have been extensively used in the evaluation of antimicrobials. The value of animals in the pharmacokinetic and pharmacodynamic characterization of antimicrobials is critically reviewed. Animal studies have demonstrated that the pharmacokinetic/pharmacodynamic (PK/PD) target determining efficacy can vary for different classes of antimicrobials. However, the magnitude of the target required for bacteriological efficacy is relatively similar for various sites of infection, various pathogens and various drugs within the same class, provided free drug levels are used.
ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(02)00022-5