Proton pump inhibitor therapy in gastro‐oesophageal reflux disease decreases the oesophageal immune response but does not reduce the formation of DNA adducts

Summary Background  Chronic oesophageal inflammation and related oxidative stress are important in the pathogenesis of erosive oesophagitis (EO) and its malignant progression. Aim  To study the effect of proton pump inhibitors (PPIs) on oesophageal cellular immune response and oxidative damage in EO...

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Published in:Alimentary pharmacology & therapeutics 2008-07, Vol.28 (1), p.127-136
Main Authors: DE JONGE, P. J. F., SIERSEMA, P. D., VAN BREDA, S. G. J., VAN ZOEST, K. P. M., BAC, D. J., LEEUWENBURGH, I., OUWENDIJK, R. J. TH, VAN DEKKEN, H., KUSTERS, J. G., KUIPERS, E. J.
Format: Article
Language:English
Subjects:
Adult
Antigens, CD - immunology
Antigens, Differentiation, Myelomonocytic - immunology
Barrett Esophagus - immunology
Biological and medical sciences
Digestive system
DNA Adducts - drug effects
DNA Adducts - metabolism
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal Reflux - drug therapy
Gastroesophageal Reflux - immunology
Humans
Immunity, Cellular
Male
Mast Cells - immunology
Medical sciences
Middle Aged
Other diseases. Semiology
Oxidative Stress - genetics
Oxidative Stress - immunology
Pharmacology. Drug treatments
Proton Pump Inhibitors - therapeutic use
T-Lymphocytes - immunology
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Summary:Summary Background  Chronic oesophageal inflammation and related oxidative stress are important in the pathogenesis of erosive oesophagitis (EO) and its malignant progression. Aim  To study the effect of proton pump inhibitors (PPIs) on oesophageal cellular immune response and oxidative damage in EO patients. Methods  Forty gastro‐oesophageal reflux disease (GERD) patients [non‐erosive reflux disease (NERD): 15, EO: 25] were included, after 7 days off antisuppressive drugs. EO patients were randomized to 20‐mg rabeprazole once daily for either 4 or 8 weeks with baseline and follow‐up endoscopy with distal oesophageal biopsies. T lymphocytes, macrophages and mast cells were quantified by immunohistochemistry. DNA adducts were measured by analysis of 8‐oxo‐deoxyguanosine levels. Results  Erosive oesophagitis patients had more T lymphocytes and CD8+ T lymphocytes in squamous epithelium than NERD patients (P = 0.001, P = 0.002, respectively). Levels of DNA adducts between both groups were, however, not different (P = 0.99). Four‐ and eight‐week rabeprazole treatment in EO patients resulted in a significant decrease in number of T lymphocytes and CD8+ T lymphocytes (all P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2008.03699.x