Comparative effects of cilazapril, carvedilol and their combination in preventing from left ventricular remodelling after acute myocardial infarction in rats

• Published in: Journal of the renin-angiotensin-aldosterone system 2002-03, Vol.3 (1), p.31-35
• Main Authors: Yang, Yuejin, Tang, Yida, Ruan, Yingmao, Li, Yongli, Zhou, Yanwen, Gao, Runlin, Chen, Jilin, Chen, Zaijia
• Format: Article
• Language: English
• Subjects: Acute Disease; Adrenergic beta-Antagonists - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Animals; Carbazoles - therapeutic use; Cilazapril - therapeutic use; Drug Therapy, Combination; Female; Hemodynamics - drug effects; Myocardial Infarction - drug therapy; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocardium - pathology; Organ Size - drug effects; Propanolamines - therapeutic use; Rats; Rats, Sprague-Dawley; Ventricular Function, Left - drug effects; Ventricular Remodeling - drug effects
• ISSN: 1470-3203; 1752-8976
• DOI: 10.3317/jraas.2002.005

Objectives To compare the effects of cilazapril, carvedilol and their combination in preventing left ventricular remodelling (LVRM) after acute myocardial infarction (AMI) in rats. Methods Twenty-four hours after left coronary artery ligation, 100 surviving AMI female Sprague-Dawley rats were randomly assigned to: (1) AMI control (n=25); (2) cilazapril (Cila, 1 mg/kg/day) (n=25); (3) carvedilol (Car, 1 mg/kg/day) (n=25), and (4) cilazapril (1 mg/kg/day)+ carvedilol (1 mg/kg/day) (combination) (n=25) groups. A sham-operated group (n=17) was selected randomly as a non-infarction control. After four weeks of therapy with the drugs given by gastric gavage, haemodynamic studies were performed, following which the rat hearts were fixed and pathologically analysed. Rats with MI size 55% were excluded. Complete data were obtained in 64 rats, comprising AMI control (n=13), Cila (n=12), Car (n=12), Combination (n=14), and sham-operated (n=13) groups. Results There were no significant differences in MI size between the four AMI groups (45.2—46.7%, p>0.05). Compared with the sham-operated group, left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV), weight (LVW), septal thickness (STh) and right ventricular weight (RVW) were all significantly increased (all p