Value of measuring serum FSH in addition to serum estradiol in a coasting programme to prevent severe OHSS

BACKGROUND: Withholding gonadotrophins (coasting) can reduce the risk of severe ovarian hyperstimulation syndrome (OHSS) in patients having assisted reproduction therapy. This requires daily serum estradiol (E2) measurements, which occasionally have been seen to decline suddenly and sharply. METHODS...

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Published in:Human reproduction (Oxford) 2002-05, Vol.17 (5), p.1217-1221
Main Authors: Al-Shawaf, T., Zosmer, A., Tozer, A., Gillott, C., Lower, A.M., Grudzinskas, J.G.
Format: Article
Language:English
Subjects:
Adult
assisted reproduction
Biological and medical sciences
coasting
Estradiol - blood
Female
Follicle Stimulating Hormone - blood
Fundamental and applied biological sciences. Psychology
Hormone metabolism and regulation
Humans
Incidence
Mammalian female genital system
OHSS
Ovarian Hyperstimulation Syndrome - epidemiology
Ovarian Hyperstimulation Syndrome - prevention & control
Preventive Medicine - methods
Prospective Studies
serum estradiol
serum FSH
Vertebrates: reproduction
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container_end_page 1221
container_issue 5
container_start_page 1217
container_title Human reproduction (Oxford)
container_volume 17
creator Al-Shawaf, T.
Zosmer, A.
Tozer, A.
Gillott, C.
Lower, A.M.
Grudzinskas, J.G.
description BACKGROUND: Withholding gonadotrophins (coasting) can reduce the risk of severe ovarian hyperstimulation syndrome (OHSS) in patients having assisted reproduction therapy. This requires daily serum estradiol (E2) measurements, which occasionally have been seen to decline suddenly and sharply. METHODS: To increase the sensitivity of the coasting programme we measured serum FSH in parallel with E2 in patients at risk of developing OHSS. RESULTS: Out of a total of 1240 cycles, 106 were coasted and in 89 both serum E2 and FSH were measured at least twice during the coasting period. One case of late severe OHSS was encountered in the study group. The serum FSH declined by a rate of 24.3 ± 4.5% per day. Serum E2 level reached a `safe level' of
doi_str_mv 10.1093/humrep/17.5.1217
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This requires daily serum estradiol (E2) measurements, which occasionally have been seen to decline suddenly and sharply. METHODS: To increase the sensitivity of the coasting programme we measured serum FSH in parallel with E2 in patients at risk of developing OHSS. RESULTS: Out of a total of 1240 cycles, 106 were coasted and in 89 both serum E2 and FSH were measured at least twice during the coasting period. One case of late severe OHSS was encountered in the study group. The serum FSH declined by a rate of 24.3 ± 4.5% per day. Serum E2 level reached a `safe level' of &lt;10 000 pmol/l when the serum FSH declined to 5 IU/l or less. 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source Oxford Journals Online
subjects Adult
assisted reproduction
Biological and medical sciences
coasting
Estradiol - blood
Female
Follicle Stimulating Hormone - blood
Fundamental and applied biological sciences. Psychology
Hormone metabolism and regulation
Humans
Incidence
Mammalian female genital system
OHSS
Ovarian Hyperstimulation Syndrome - epidemiology
Ovarian Hyperstimulation Syndrome - prevention & control
Preventive Medicine - methods
Prospective Studies
serum estradiol
serum FSH
Vertebrates: reproduction
title Value of measuring serum FSH in addition to serum estradiol in a coasting programme to prevent severe OHSS
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