Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 prod...

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Bibliographic Details
Published in:Breast cancer research and treatment 2008-07, Vol.110 (2), p.223-226
Main Authors: Faggioli, Francesca, Soldati, Sabina, Scanziani, Eugenio, Catò, Enrica Mira, Adorni, Fulvio, Vezzoni, Paolo, Noonan, Douglas M., Sacco, Maria Grazia
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - therapy
Cancer research
Cancer therapies
Cytokines
Cytokines - metabolism
DNA - metabolism
Female
Gene therapy
Genetic Therapy - methods
Gynecology. Andrology. Obstetrics
Humans
Interleukin-12 - genetics
Mammary gland diseases
Mammary Neoplasms, Animal - genetics
Mammary Neoplasms, Animal - therapy
Mammary Tumor Virus, Mouse - metabolism
Medical sciences
Medicine
Medicine & Public Health
Mice
Mice, Nude
Mice, Transgenic
Neoplasm Metastasis
Neoplasm Transplantation
Oncology
Preclinical Study
Tumors
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Summary:Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-007-9713-6