Evaluation of myocardial perfusion and function by gated SPECT in patients with Behçet’s disease

• Published in: Annals of nuclear medicine 2008-05, Vol.22 (4), p.287-295
• Main Authors: Kaya, Eser, Saglam, Hayrettin, Ciftci, İsmail, Kulac, Mustafa, Karaca, Semsettin, Melek, Mehmet
• Format: Article
• Language: English
• Subjects: Adult; Behcet Syndrome - diagnostic imaging; Behcet Syndrome - physiopathology; Coronary Angiography; Coronary Circulation; Exercise Test; Female; Gated Blood-Pool Imaging; Humans; Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Myocardial Contraction; Nuclear Medicine; Original Article; Radiology; Radiopharmaceuticals - pharmacokinetics; Stroke Volume; Technetium Tc 99m Sestamibi - pharmacokinetics; Tomography, Emission-Computed, Single-Photon; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left
• ISSN: 0914-7187; 1864-6433
• DOI: 10.1007/s12149-007-0115-y

Background Behçet’s disease (BD) is a systemic multi-system vasculitis that can have a wide range of effects on the cardiovascular system. Objective To determine the existence of myocardial perfusion defects caused by coronary microvascular dysfunction in BD and to evaluate coronary arterial distribution and left ventricular systolic function by gated single-photon emission computed tomography (SPECT). Methods The study population consisted of 23 (15 men and 8 women) patients with BD and 20 healthy controls (12 men and 8 women). Technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) gated SPECT studies were performed at stress and rest in a 2-day protocol. Stress and rest left ventricular ejection fraction (LVEF) were calculated. Using non-gated SPECT images myocardial perfusion scores [summed stress score (SSS), summed rest score (SRS), summed difference score (SDS), and fix defect score (FDS)] and perfusion defect extent as percentage (stress, rest ischemic, and fix %LV) were determined. Using gated SPECT images, wall motion score indices (stress wall motion score indices and rest wall motion score indices) were calculated. Coronary angiography (CAG) was applied to patients with abnormal myocardial perfusion scintigraphy (MPS). Results The mean ages of the BD and control groups were 39.3 ± 10.6 years and 36.2 ± 8.3 years, respectively. No statistically significant differences were observed between the two groups regarding clinical features and cardiologic findings. Abnormal MPS was found in 13 (56.5%) of the BD patients; 3 patients had non-transmural infarcts and 10 patients reversible perfusion defects. Reversible perfusion defects were also found in two controls (10.0%). When the two groups were compared regarding the gated SPECT findings, differences were determined in the following parameters; SSS, SRS, SDS, FDS, stress and rest LVEF, stress and rest %LV, and stress and rest WMSI. In the BD group, when gated SPECT results were compared between those with and without abnormal MPS, differences were determined in SSS, SRS, SDS, FDS, stress and rest %LV, and stress and rest WMSI. Epicardial coronary arteries were normal in CAG. Conclusions Myocardial perfusion and function are disturbed owing to influenced coronary microvascularity in BD, and CAG is frequently observed to be normal. Gated SPECT is a non-invasive reliable method that simultaneously evaluates the existence, extent and severity of myocardial ischemia or infarction and the wall movements in