The Relationship Between Neuropsychiatric, Clinical, and Laboratory Variables and Quality of Life of Chinese Patients with Systemic Lupus Erythematosus

Objective To investigate the role of neuropsychiatric (NP), clinical, and laboratory variables in influencing the health related quality of life (HRQOL) of Chinese patients with systemic lupus erythematosus (SLE). Methods The Medical Outcomes Study Short Form-36 was applied in a cohort of 291 patien...

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Bibliographic Details
Published in:Journal of rheumatology 2008-06, Vol.35 (6), p.1038-1045
Main Authors: TAM, Lai-Shan, WONG, Adrian, MOK, Vincent C. T, ZHU, Yan-Er, KWOK, Lai-Wa, LI, Tena K, WONG, Kong-Chiu, LI, Edmund K
Format: Article
Language:English
Subjects:
Adult
Age Factors
Anxiety - complications
Biological and medical sciences
China
Depression - complications
Diseases of the osteoarticular system
Female
Humans
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - psychology
Male
Medical sciences
Middle Aged
Quality of Life
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Serum Albumin
Severity of Illness Index
Sex Factors
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Summary:Objective To investigate the role of neuropsychiatric (NP), clinical, and laboratory variables in influencing the health related quality of life (HRQOL) of Chinese patients with systemic lupus erythematosus (SLE). Methods The Medical Outcomes Study Short Form-36 was applied in a cohort of 291 patients with SLE. At the time of HRQOL testing all patients underwent a clinical and laboratory evaluation together with measures of disease activity and damage. Patients also submitted to a battery of NP tests. Results Using multivariate analysis, NP involvement-ever was associated with impairment of the general health subscale. Cerebrovascular disease and mononeuropathy were associated with impairment of the physical function subscale, while the latter was also associated with impairment of the role-emotional subscale. Cognitive impairment was associated with impairment of the mental health subscale. The Hospital Anxiety and Depression (HAD) depression score was associated with impairment of all the 8 subscales, physical, and mental summary scores. The HAD anxiety score was associated with impairment of predominantly mental function. Active arthritis, lower education level, and serum albumin levels were associated with impairment of predominantly physical function. Advancing age and damage were associated with impairment of both physical and mental function. Low hemoglobin level and female sex were associated with impairment of predominantly mental function. Conclusion NP involvement and low-grade inflammation as reflected by low serum albumin and hemoglobin concentrations were associated with impaired HRQOL in patients with SLE, independent of other sociodemographic and clinical variables. Key Indexing Terms: SYSTEMIC LUPUS ERYTHEMATOSUS CHINESE NEUROPSYCHIATRIC HEALTH RELATED QUALITY OF LIFE
ISSN:0315-162X
1499-2752