Relation Between the Assessment of Microvascular Injury by Cardiovascular Magnetic Resonance and Coronary Doppler Flow Velocity Measurements in Patients With Acute Anterior Wall Myocardial Infarction

• Published in: Journal of the American College of Cardiology 2008-06, Vol.51 (23), p.2230-2238
• Main Authors: Hirsch, Alexander, MD, Nijveldt, Robin, MD, Haeck, Joost D.E., MD, Beek, Aernout M., MD, Koch, Karel T., MD, PhD, Henriques, José P.S., MD, PhD, van der Schaaf, Rene J., MD, Vis, Marije M., MD, Baan, Jan, MD, PhD, de Winter, Robbert J., MD, PhD, Tijssen, Jan G.P., PhD, van Rossum, Albert C., MD, PhD, Piek, Jan J., MD, PhD
• Format: Article
• Language: English
• Subjects: Angioplasty, Balloon, Coronary; Blood Flow Velocity; Blood pressure; Cardiology; Cardiovascular; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - physiopathology; Confidence intervals; Coronary Vessels - diagnostic imaging; Diastole; Endothelium, Vascular - physiopathology; Female; Gadolinium; Heart attacks; Humans; Internal Medicine; Kinases; Magnetic Resonance Imaging; Male; Medical prognosis; Middle Aged; Myocardial Infarction - diagnosis; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - physiopathology; Prognosis; Prospective Studies; Regression analysis; Risk Factors; Studies; Systole; Time Factors; Ultrasonography, Doppler
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2008.01.064

Relation Between the Assessment of Microvascular Injury by Cardiovascular Magnetic Resonance and Coronary Doppler Flow Velocity Measurements in Patients With Acute Anterior Wall Myocardial Infarction Alexander Hirsch, Robin Nijveldt, Joost D. E. Haeck, Aernout M. Beek, Karel T. Koch, José P. S. Henriques, Rene J. van der Schaaf, Marije M. Vis, Jan Baan, Jr, Robbert J. de Winter, Jan G. P. Tijssen, Albert C. van Rossum, Jan J. Piek We studied the relation between the presence and severity of microvascular obstruction measured by cardiovascular magnetic resonance (CMR) and intracoronary Doppler flow measurements in 27 patients with a first acute anterior wall myocardial infarction treated by primary percutaneous coronary intervention. The extent and size of microvascular obstruction as assessed by late gadolinium-enhanced CMR correlated well with coronary blood flow velocity characteristics of microvascular injury, such as the presence of early systolic retrograde flow, rapid deceleration of diastolic flow, and a reduced coronary flow velocity reserve. This relation was independent of the size and transmural extent of the infarcted myocardium.