Sugar intolerance: Origin and mechanisms of symptoms?

The origin and mechanisms of symptoms in sugar intolerance were studied in 8 healthy volunteers. For two test periods, volunteers swallowed a probe with perfused catheters and an infusion catheter which migrated into the colon. A meal containing 40 g lactulose or 40 g sucrose was ingested; the sucro...

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Bibliographic Details
Published in:Digestive diseases and sciences 2002-04, Vol.47 (4), p.886-893
Main Authors: JOUST, Pauline, SABATE, Jean-Marc, COFFIN, Benoit, BOUHNIK, Yoram, LEMANN, Marc, JIAN, Raymond, RAMBAUD, Jean-Claude, FLOURIE, Bernard
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Breath Tests
Carbohydrate Metabolism, Inborn Errors - metabolism
Carbohydrate Metabolism, Inborn Errors - physiopathology
Colon - physiopathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Agents - metabolism
Gastrointestinal Motility
Humans
Hydrogen
Intestine, Small - physiopathology
Lactulose - metabolism
Male
Medical sciences
Other diseases. Semiology
Single-Blind Method
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Sucrose - adverse effects
Sucrose - metabolism
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Summary:The origin and mechanisms of symptoms in sugar intolerance were studied in 8 healthy volunteers. For two test periods, volunteers swallowed a probe with perfused catheters and an infusion catheter which migrated into the colon. A meal containing 40 g lactulose or 40 g sucrose was ingested; the sucrose meal was followed by colonic infusion of 40 g lactulose in order to bypass the small intestine. Recordings of small intestinal and colonic motility were performed. Abdominal pain, bloating, borborygmi, and flatulence were similar during both periods. Both meals increased small intestinal and colonic motility. Only 37% of the symptoms coincided in time with colonic motor events. Symptoms were not related to a specific motor event and were not correlated with breath hydrogen excretion. In conclusion, symptoms of sugar intolerance originate from the colon. They are not related to specific phasic motor events or to breath hydrogen excretion.
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1014772907681