Effect of oral nitroglycerin and cold stress on myocardial perfusion in areas subtended by stenosed and nonstenosed coronary arteries

Physical obstruction and coronary vasoconstriction mediated by adrenergic stress are believed to be responsible for episodes of myocardial hypoperfusion and angina. Nitroglycerin relieves symptoms by reducing preload and dilating epicardial vessels. The net perfusion change and relation to stenosis...

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Bibliographic Details
Published in:The American journal of cardiology 2002-05, Vol.89 (9), p.1019-1024
Main Authors: Bøttcher, Morten, Madsen, Mette M, Randsbæk, Flemming, Refsgaard, Jens, Dørup, Inge, Sørensen, Keld, Nielsen, Torsten Toftegaard
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Biological and medical sciences
Blood vessels
Brachial Artery - diagnostic imaging
Brachial Artery - drug effects
Brachial Artery - physiopathology
Cardiology. Vascular system
Cold Temperature
Coronary Circulation - drug effects
Coronary heart disease
Coronary Stenosis - diagnostic imaging
Coronary Stenosis - drug therapy
Coronary Stenosis - physiopathology
Coronary Vessels - diagnostic imaging
Coronary Vessels - physiopathology
Drugs
Female
Heart
Heart - diagnostic imaging
Heart - drug effects
Heart - physiopathology
Humans
Male
Medical sciences
Middle Aged
Nitroglycerin - administration & dosage
Stress, Physiological - physiopathology
Temperature
Tomography, Emission-Computed
Ultrasonography
Vascular Patency
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Summary:Physical obstruction and coronary vasoconstriction mediated by adrenergic stress are believed to be responsible for episodes of myocardial hypoperfusion and angina. Nitroglycerin relieves symptoms by reducing preload and dilating epicardial vessels. The net perfusion change and relation to stenosis severity of nitroglycerin and adrenergic stress have been debated. This study aimed to evaluate whether oral nitroglycerin and adrenergic stress alters perfusion in myocardial segments subtended by stenosed and nonstenosed coronary arteries. Myocardial perfusion was quantified (using N-13-ammonia positron emission tomography [PET]) at rest, after oral nitroglycerin 400 μg, and after cold stress in 25 patients with coronary artery disease (62 ± 9 years, 21 men) and in 30 controls (34 ± 9 years, 22 men). Myocardial perfusion was quantified in areas supplied by stenosed (>70%) and nonstenosed (
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(02)02268-3