Synthesis and antifungal activity of new N-(1-phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides

N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides 6, with a Benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazinones 5 with potassium iodide for 1 h in order to study the role on the antifungal activity of...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 2002-03, Vol.57 (3), p.183-187
Main Authors: Raffa, Demetrio, Daidone, Giuseppe, Plescia, Fabiana, Schillaci, Domenico, Maggio, Benedetta, Torta, Livio
Format: Article
Language:English
Subjects:
Antifungal activity
Antifungal Agents - chemical synthesis
Antifungal Agents - pharmacology
Benzamides - chemical synthesis
Benzamides - pharmacology
Biological and medical sciences
Chemical control
Colony Count, Microbial
Control
Fundamental and applied biological sciences. Psychology
Fungal plant pathogens
Fungi - drug effects
Fungi - growth & development
Indazoles - chemical synthesis
Indazoles - pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-2-iodobenzamides
N-(Indazol-3-yl)-2-iodobenzamides
N-(Indazol-5-yl)-2-iodobenzamides
Phytopathology. Animal pests. Plant and forest protection
Pyrazoles - chemical synthesis
Pyrazoles - pharmacology
Spectrophotometry, Infrared
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Summary:N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides 6, with a Benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazinones 5 with potassium iodide for 1 h in order to study the role on the antifungal activity of the N-substitution with an aromatic heterocyclic system on benzamide moiety. Among the tested iododerivatives, compounds 6d, f, g, h possess interesting activities toward some phytopathogenic fungal strains.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(01)01190-9