Conservation of Pax gene expression in ectodermal placodes of the lamprey

Ectodermal placodes contribute to the cranial ganglia and sense organs of the head and, together with neural crest cells, represent defining features of the vertebrate embryo. The identity of different placodes appears to be specified in part by the expression of different Pax genes, with Pax-3/7 cl...

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Bibliographic Details
Published in:Gene 2002-04, Vol.287 (1), p.129-139
Main Authors: McCauley, David W, Bronner-Fraser, Marianne
Format: Article
Language:English
Subjects:
Agnatha
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Conservation
Conserved Sequence - genetics
DNA, Complementary - chemistry
DNA, Complementary - genetics
DNA-Binding Proteins - genetics
Ectoderm - metabolism
Ectodermal placode
Embryo, Nonmammalian - metabolism
Embryonic Development
Gene expression
Gene Expression Regulation, Developmental
Homeodomain Proteins - genetics
In Situ Hybridization
Lampreys - embryology
Lampreys - genetics
Life Sciences (General)
Molecular Sequence Data
Multigene Family - genetics
Pax-2
Pax-2 gene
Pax-3 gene
Pax-7
Pax-7 gene
PAX2 Transcription Factor
PAX7 Transcription Factor
Petromyzontidae
Phylogeny
placodes
sense organs
Sequence Alignment
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Space life sciences
Transcription Factors - genetics
Vertebrata
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Summary:Ectodermal placodes contribute to the cranial ganglia and sense organs of the head and, together with neural crest cells, represent defining features of the vertebrate embryo. The identity of different placodes appears to be specified in part by the expression of different Pax genes, with Pax-3/7 class genes being expressed in the trigeminal placode of mice, chick, frogs and fish, and Pax-2/5/8 class genes expressed in the otic placode. Here, we present the cloning and expression pattern of lamprey Pax-7 and Pax-2, which mark the trigeminal and otic placodes, respectively, as well as other structures characteristic of vertebrate Pax genes. These results suggest conservation of Pax genes and placodal structures in basal and derived vertebrates.
ISSN:0378-1119
1879-0038
DOI:10.1016/S0378-1119(01)00894-0