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Characteristics of hepatitis B virus genotype G coinfected with genotype H in chimeric mice carrying human hepatocytes

Abstract Accumulated evidence indicated that hepatitis B virus genotype G (HBV/G) is present exclusively in coinfection with other HBV genotypes. In Mexico, HBV/G from 6 men who had sex with men were coinfected with HBV/H. Phylogenetically complete genomes of the 6 Mexican HBV/G strains were closely...

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Published in:Virology (New York, N.Y.) N.Y.), 2008-07, Vol.376 (2), p.408-415
Main Authors: Tanaka, Yasuhito, Sanchez, Laura V, Sugiyama, Masaya, Sakamoto, Tomoyuki, Kurbanov, Fuat, Tatematsu, Kanako, Roman, Sonia, Takahashi, Satoru, Shirai, Tomoyuki, Panduro, Arturo, Mizokami, Masashi
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Language:English
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Summary:Abstract Accumulated evidence indicated that hepatitis B virus genotype G (HBV/G) is present exclusively in coinfection with other HBV genotypes. In Mexico, HBV/G from 6 men who had sex with men were coinfected with HBV/H. Phylogenetically complete genomes of the 6 Mexican HBV/G strains were closely related to previous ones from the US/Europe. Using uPA/SCID mice with human hepatocytes, monoinfection with HBV/G did not result in detectable HBV DNA in serum, whereas superinfection with HBV/G at week 10 inoculated HBV/H when HBV/H DNA was elevated to > 107 copies/mL has enhanced the replication of HBV/G. The HBV/G was enhanced in another 3 inoculated with a serum passage containing HBV/G with a trace of HBV/H. Coinfection of mice with HBV/G and H induced fibrosis in the liver. In conclusion, the replication of HBV/G can be enhanced remarkably when it is coinfected with HBV/H. Coinfection with HBV/G may be directly cytopathic in immunosuppressive conditions.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2008.04.001