Knowing a Nascent Synapse When You See It

To understand brain development, we must learn how synapse formation shapes functional neural circuits. At the heart of this process lies the nascent synapse—an enigmatic structure spanning the developmental gap between initial cell-cell contact and the mature synapse. New experimental techniques ar...

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Bibliographic Details
Published in:Neuron 2002-04, Vol.34 (3), p.333-336
Main Authors: Ahmari, Susanne E., Smith, Stephen J.
Format: Article
Language:English
Subjects:
Animals
Cell culture
Central Nervous System - cytology
Central Nervous System - physiology
Fluorescent Dyes - metabolism
Hippocampus - cytology
Hippocampus - metabolism
Immunohistochemistry
Methods
Microscopy
Neurons - physiology
Neurons - ultrastructure
Proteins
Recombinant Fusion Proteins - metabolism
Synapses - physiology
Synapses - ultrastructure
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Summary:To understand brain development, we must learn how synapse formation shapes functional neural circuits. At the heart of this process lies the nascent synapse—an enigmatic structure spanning the developmental gap between initial cell-cell contact and the mature synapse. New experimental techniques are beginning to illuminate the processes involved in synaptogenesis, but much remains to be learned, including simply how to recognize the synapse in its nascent form.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(02)00685-2