AIDS vaccine: Efficacy, safety and ethics

Summary Human immunodeficiency virus (HIV) has infected 50 million people worldwide and killed 16 million so far, and the epidemic is still spreading with 16,000 new cases of HIV infection daily and a projection of 100 million infected individuals by the end of the next decade. There is no question...

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Bibliographic Details
Published in:Vaccine 2008-06, Vol.26 (24), p.3072-3077
Main Authors: Veljkovic, Veljko, Veljkovic, Nevena, Glisic, Sanja, Ho, Mae-Wan
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
AIDS vaccine
AIDS Vaccines - adverse effects
AIDS Vaccines - immunology
AIDS Vaccines - therapeutic use
Allergy and Immunology
Applied microbiology
Biological and medical sciences
Consumer Product Safety
Efficacy
Fundamental and applied biological sciences. Psychology
HIV
HIV Envelope Protein gp120 - immunology
HIV Infections - prevention & control
HIV-1 - immunology
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Medical research
Medical sciences
Microbiology
Pandemics
Public health
Safety
Vaccination - adverse effects
Vaccination - ethics
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Synthetic - adverse effects
Vaccines, Synthetic - therapeutic use
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Summary Human immunodeficiency virus (HIV) has infected 50 million people worldwide and killed 16 million so far, and the epidemic is still spreading with 16,000 new cases of HIV infection daily and a projection of 100 million infected individuals by the end of the next decade. There is no question that a safe and effective acquired immunodeficiency syndrome (AIDS) vaccine is urgently needed to bring the current AIDS pandemic under control. But, is preventive AIDS vaccine an attainable goal? Unfortunately, the results of many laboratory and clinical studies over the past two decades are not encouraging. We comment on the efficacy, safety and ethics of AIDS vaccine, and the urgent need for a new strategy for AIDS vaccine development.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2007.11.061