Cutaneous lichenoid graft-versus-host disease mimicking lupus erythematosus

Graft-versus-host disease (GVHD) is the main complication of allogeneic bone marrow transplantation and the skin is the most commonly involved organ. The clinical presentation is varied and may resemble autoimmune diseases, such as scleroderma, lichen planus or lichen sclerosus. Chronic GVHD present...

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Bibliographic Details
Published in:Lupus 2008-06, Vol.17 (6), p.591-595
Main Authors: Goiriz, R, Peñas, PF, Delgado-Jiménez, Y, Fernández-Herrera, J, Aragüés-Montañés, M, Fraga, J, García-Díez, A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bone Marrow Transplantation - adverse effects
Fatal Outcome
Female
Graft vs Host Disease - diagnosis
Graft vs Host Disease - etiology
Graft vs Host Disease - pathology
Humans
Lichen Sclerosus et Atrophicus - diagnosis
Lichen Sclerosus et Atrophicus - etiology
Lichen Sclerosus et Atrophicus - pathology
Lupus Erythematosus, Cutaneous - pathology
Male
Middle Aged
Skin - pathology
Transplantation, Homologous - adverse effects
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Summary:Graft-versus-host disease (GVHD) is the main complication of allogeneic bone marrow transplantation and the skin is the most commonly involved organ. The clinical presentation is varied and may resemble autoimmune diseases, such as scleroderma, lichen planus or lichen sclerosus. Chronic GVHD presenting with a butterfly malar rash mimicking lupus erythematosus is uncommon. We report a series of five patients with cutaneous lichenoid GVHD that presented with a butterfly malar rash. Two of our patients had positive antinuclear antibody titres. The evolution was poor with development of sclerodermatous GVHD lesions in three patients and relapse of their haematological disease in two.
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203307087874