The JT-area indicates dispersion of repolarization in dogs with atrioventricular block

Heterogeneity in cardiac repolarization (Delta APD) is known to be arrhythmic. In the dog model of chronic complete AV-block and acquired long QT syndrome, an increase in Delta MAPD (defined as left ventricular monophasic action potential duration (MAPD) minus right ventricular MAPD) is often associ...

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Bibliographic Details
Published in:Journal of interventional cardiac electrophysiology 2002-06, Vol.6 (2), p.113-120
Main Authors: VAN OPSTAL, Jurren M, VERDUYN, S. Cora, WINCKELS, Stephan K. G, LEERSSEN, Hendrik M, LEUNISSEN, Jet D. M, WELLENS, Hein J. J, VOS, Marc A
Format: Article
Language:English
Subjects:
Action Potentials
Animals
Anti-Arrhythmia Agents - pharmacology
Biological and medical sciences
Body Surface Potential Mapping
Cromakalim - pharmacology
Disease Models, Animal
Dogs
Electrocardiography
Electrocardiography. Vectocardiography
Electrodiagnosis. Electric activity recording
Electrophysiologic Techniques, Cardiac
Heart Block - physiopathology
Heart Conduction System - drug effects
Heart Conduction System - physiopathology
Heart Ventricles - physiopathology
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Signal Processing, Computer-Assisted
Sulfonamides - pharmacology
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Summary:Heterogeneity in cardiac repolarization (Delta APD) is known to be arrhythmic. In the dog model of chronic complete AV-block and acquired long QT syndrome, an increase in Delta MAPD (defined as left ventricular monophasic action potential duration (MAPD) minus right ventricular MAPD) is often associated with changes in T-wave morphology. The purpose of this study was to correlate known changes in Delta MAPD with the planimetric total area of the T-wave on the surface ECG (integral of J-T, mVx ms). The relationship between Delta MAPD and total area of the T-wave (i.e., JT-area) was assessed in four different protocols with different types of dispersion: (1) class III drugs followed by levcromakalim (n= 7), (2) LAD coronary artery occlusion and reperfusion (n = 6), (3) dronedarone i.v., an amiodarone like agent (n = 5) and (4) steady state pacing at cycle lengths of 1000 ms and 500 ms (n = 5). Class III drugs increased Delta MAPD (55 +/- 40 ms to 120 +/- 50 ms(#), P
ISSN:1383-875X
1572-8595
DOI:10.1023/A:1015302415323