Antimalarial responses in Anopheles gambiae: from a complement-like protein to a complement-like pathway

Malaria transmission between humans depends on the ability of Anopheles mosquitoes to support Plasmodium development. New perspectives in vector control are emerging from understanding the mosquito immune system, which plays critical roles in parasite recognition and killing. A number of factors con...

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Bibliographic Details
Published in:Cell host & microbe 2008-06, Vol.3 (6), p.364-374
Main Authors: Blandin, Stéphanie A, Marois, Eric, Levashina, Elena A
Format: Article
Language:English
Subjects:
Animals
Anopheles - genetics
Anopheles - immunology
Anopheles - virology
Antimalarials - chemistry
Antimalarials - immunology
Complement System Proteins - chemistry
Complement System Proteins - immunology
Female
Host-Parasite Interactions
Humans
Insect Proteins - chemistry
Insect Proteins - immunology
Insect Vectors - genetics
Insect Vectors - immunology
Insect Vectors - virology
Malaria, Falciparum - immunology
Male
Plasmodium falciparum - immunology
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Summary:Malaria transmission between humans depends on the ability of Anopheles mosquitoes to support Plasmodium development. New perspectives in vector control are emerging from understanding the mosquito immune system, which plays critical roles in parasite recognition and killing. A number of factors controlling this process have been recently identified, and key among them is TEP1, a homolog of human complement factor C3 whose binding to the parasite surface targets it for subsequent killing. Here, we review our current knowledge of mosquito factors that respond to Plasmodium infection and elaborate on the activity and mode of action of the TEP1 complement-like pathway.
ISSN:1931-3128
1934-6069
DOI:10.1016/j.chom.2008.05.007