Monitoring minimal residual disease in patients with MLL-AF6 fusion transcript-positive acute myeloid leukemia following allogeneic bone marrow transplantation

Acute myeloid leukemia (AML) patients with chromosome 11q23 abnormalities or MLL rearrangements have a poor prognosis when treated with conventional chemotherapy. However, the efficacy of allogeneic bone marrow transplantation (BMT) for this type of leukemia is not yet clear. We describe 2 MLL-AF6 f...

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Bibliographic Details
Published in:International journal of hematology 2002-04, Vol.75 (3), p.298-301
Main Authors: TAKATSUKI, Hiroshi, YUFU, Yuji, TACHIKAWA, Yoshimichi, UIKE, Naokuni
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Bone Marrow Transplantation
Bone marrow, stem cells transplantation. Graft versus host reaction
Chromosome Aberrations
Chromosomes, Human, Pair 11
Female
Hematologic and hematopoietic diseases
Humans
Leukemia, Myeloid - genetics
Leukemia, Myeloid - pathology
Leukemia, Myelomonocytic, Acute - genetics
Leukemia, Myelomonocytic, Acute - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Middle Aged
Monitoring, Physiologic
Myeloid-Lymphoid Leukemia Protein
Neoplasm, Residual - genetics
Neoplasm, Residual - pathology
Neoplasm, Residual - therapy
Oncogene Proteins, Fusion - genetics
Reverse Transcriptase Polymerase Chain Reaction
Sensitivity and Specificity
Transcription, Genetic
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Description
Summary:Acute myeloid leukemia (AML) patients with chromosome 11q23 abnormalities or MLL rearrangements have a poor prognosis when treated with conventional chemotherapy. However, the efficacy of allogeneic bone marrow transplantation (BMT) for this type of leukemia is not yet clear. We describe 2 MLL-AF6 fusion transcript-positive AML patients treated with allogeneic BMT who were monitored for minimal residual disease (MRD) by reverse transcriptase polymerase chain reaction. Although long survival or cure of this type of AML is rarely reported, 1 patient had durable remissions. Fusion transcripts disappeared in 1 patient but not in the other, even after the graft-versus-host disease effect was increased by the discontinuation of immmunosuppressive therapy. This is the first report of MRD and the probability of graft-versus-leukemia effects following BMT in AML patients who are MLL-AF6 fusion transcript positive.
ISSN:0925-5710
1865-3774
DOI:10.1007/BF02982045