Synthesis and structure–activity relationship of aminopyrimidine IKK2 inhibitors

The synthesis and structure–activity relationship of a novel series of aminopyrimidines is exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported. The synthesis and structure–activity relationship of a novel series of aminopyrimidines ar...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2008-06, Vol.18 (12), p.3622-3627
Main Authors: Bingham, Alistair H., Davenport, Richard J., Fosbeary, Richard, Gowers, Lewis, Knight, Roland L., Lowe, Christopher, Owen, David A., Parry, David M., Pitt, Will R.
Format: Article
Language:English
Subjects:
Aminopyrimidine
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cell Line, Tumor
Drug Evaluation, Preclinical
E-Selectin - metabolism
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Humans
I-kappa B Kinase - antagonists & inhibitors
IKK2
Inflammation
Kinase
Medical sciences
Models, Molecular
Molecular Structure
Pharmacology. Drug treatments
Pyrimidines - chemical synthesis
Pyrimidines - chemistry
Pyrimidines - pharmacology
Stereoisomerism
Structure-Activity Relationship
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Summary:The synthesis and structure–activity relationship of a novel series of aminopyrimidines is exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported. The synthesis and structure–activity relationship of a novel series of aminopyrimidines are exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported.
ISSN:0960-894X
0968-0896
1464-3405
1464-3391
DOI:10.1016/j.bmcl.2008.04.062