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Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives

Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2002-05, Vol.12 (10), p.1399-1404
Main Authors: Wyatt, Paul G, Allen, Michael J, Chilcott, Josie, Foster, Alison, Livermore, David G, Mordaunt, Jackie E, Scicinski, Jan, Woollard, Patrick M
Format: Article
Language:English
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Summary:Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257. Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity. Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257. Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(02)00159-2