Invasive papillary adenocarcinoma of the colon

Colonic adenocarcinomas are among the most common type of tumors. In this report, we present the morphologic, immunohistochemical, and microsatellite findings of 2 cases with a distinct invasive papillary component. Both tumors arose from polyps in middle-aged patients, followed an aggressive course...

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Bibliographic Details
Published in:Human pathology 2002-03, Vol.33 (3), p.372-375
Main Authors: Palazzo, Juan P., Edmonston, Tina Bocker, Chaille-Arnold, Linda M., Burkholder, Susan
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Adenocarcinoma, Papillary - chemistry
Adenocarcinoma, Papillary - secondary
Adenocarcinoma, Papillary - surgery
Adenoma, Villous - chemistry
Adenoma, Villous - pathology
Adenoma, Villous - surgery
Adult
Biological and medical sciences
Biomarkers, Tumor - analysis
Carrier Proteins
colonic adenocarcinoma
Colonic Neoplasms - chemistry
Colonic Neoplasms - pathology
Colonic Neoplasms - surgery
Colorectal Neoplasms, Hereditary Nonpolyposis - pathology
Diagnosis, Differential
DNA, Neoplasm - analysis
DNA-Binding Proteins
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
MutL Protein Homolog 1
MutS Homolog 2 Protein
Neoplasm Proteins - analysis
Neoplasms, Second Primary
Nuclear Proteins
papillary
Proto-Oncogene Proteins - analysis
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Description
Summary:Colonic adenocarcinomas are among the most common type of tumors. In this report, we present the morphologic, immunohistochemical, and microsatellite findings of 2 cases with a distinct invasive papillary component. Both tumors arose from polyps in middle-aged patients, followed an aggressive course, and showed a superficial adenomatous component. The immunohistochemical stains showed that the tumor cells were negative for p27 and p53; both tumors were microsatellite stable, that is, with no microsatellite instability in the 6 markers studied, and there was no loss of the mismatch repair proteins hMSH2 or hMLH1. These findings suggest that these tumors follow the tumor-suppressor pathway and represent an aggressive subtype of colonic adenocarcinoma. HUM PATHOL 33:372-375. Copyright 2002, Elsevier Science (USA). All rights reserved.
ISSN:0046-8177
1532-8392
DOI:10.1053/hupa.2002.32228