Endocytic transport of integrins during cell migration and invasion

Early studies describing the endocytic–exocytic cycling of integrins prompted proposals that this process regulates cell migration. However, it is only relatively recently that more detailed descriptions of the molecular machinery responsible for directing integrin trafficking have enabled us to pro...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cell biology 2008-06, Vol.18 (6), p.257-263
Main Authors: Caswell, Patrick, Norman, Jim
Format: Article
Language:English
Subjects:
Animals
Cell Membrane - metabolism
Cell Movement
Dimerization
Endocytosis
Exocytosis
Extracellular Matrix - metabolism
Humans
Integrins - metabolism
Light
Models, Biological
Neoplasm Invasiveness
Pathology
Proteins - chemistry
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Early studies describing the endocytic–exocytic cycling of integrins prompted proposals that this process regulates cell migration. However, it is only relatively recently that more detailed descriptions of the molecular machinery responsible for directing integrin trafficking have enabled us to properly address the role of these events during the various modes of cell migration. Here, we review recent advances in our understanding of the protein complexes and signallosomes controlling integrin trafficking, and we describe how these influence cell migration and signalling events downstream of integrin engagement. Furthermore, we consider recent evidence for integrin trafficking during the invasive migration of cancer cells through 3D microenvironments, and conclude with a discussion of the use of novel photoactivatable integrin probes to visualize these processes.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2008.03.004