Protective role of cyclooxygenase (COX) inhibitors in burn-induced intestinal and liver damage

The aim of this study was to investigate the role of cyclooxygenase (COX) inhibition in intestinal motility and in the extent of tissue injury of the small intestine and liver with the use of various COX inhibitors. Wistar albino rats were exposed to 90 °C water bath for 10 s. The intestinal transit...

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Bibliographic Details
Published in:Burns 2002-05, Vol.28 (3), p.209-214
Main Authors: Oktar, Berna K., Çakir, Barış, Mutlu, Nilgün, Çelikel, Çiǧdem, Alican, İnci
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Burn
Burns
Cyclooxygenase
Cyclooxygenase Inhibitors - pharmacology
Cyclooxygenase Inhibitors - therapeutic use
Gastrointestinal Motility - drug effects
Glutathione - analysis
Intestinal motility
Intestinal Mucosa - metabolism
Intestines - drug effects
Intestines - injuries
Lipid Peroxidation
Liver - drug effects
Liver - injuries
Liver - metabolism
Liver Function Tests
Medical sciences
Neutrophils
Oxidant damage
Peroxidase - analysis
Rats
Rats, Wistar
Traumas. Diseases due to physical agents
Tropical medicine
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Summary:The aim of this study was to investigate the role of cyclooxygenase (COX) inhibition in intestinal motility and in the extent of tissue injury of the small intestine and liver with the use of various COX inhibitors. Wistar albino rats were exposed to 90 °C water bath for 10 s. The intestinal transit index decreased compared to control group and treatment with nimesulide (NIM; 10 mg/kg, subcutaneously) or piroxicam (Pir; 5 mg/kg, orogastrically) reversed this effect significantly. The intestinal and liver glutathione levels showed a significant decrease in the burn group compared to sham ( P
ISSN:0305-4179
1879-1409
DOI:10.1016/S0305-4179(02)00004-9