Protective Role of DC-SIGN (CD209) Neck-Region Alleles with <5 Repeat Units in HIV-1 Transmission

To investigate the role that DC-SIGN neck-region length variation plays in HIV-1 transmission, we studied 530 HIV-1-positive and 341 HIV-1-negative individuals in China. The carrier frequency of a DC-SIGN allele with

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Bibliographic Details
Published in:The Journal of Infectious Diseases 2008-07, Vol.198 (1), p.68-71
Main Authors: Zhang, Jing, Zhang, Xinsheng, Fu, Jihua, Bi, Zhenqiang, Arheart, Kristopher L., Barreiro, Luis B., Quintana-Murci, Lluis, Pahwa, Savita, Liu, Huanliang
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Case-Control Studies
Cell Adhesion Molecules - chemistry
Cell Adhesion Molecules - genetics
China
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
Genetic Variation
Genotype
HIV Infections - genetics
HIV Infections - transmission
HIV-1
Human immunodeficiency virus 1
Humans
Infectious diseases
Lectins, C-Type - chemistry
Lectins, C-Type - genetics
Male
Medical sciences
Microbiology
Miscellaneous
Odds Ratio
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - genetics
Virology
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Description
Summary:To investigate the role that DC-SIGN neck-region length variation plays in HIV-1 transmission, we studied 530 HIV-1-positive and 341 HIV-1-negative individuals in China. The carrier frequency of a DC-SIGN allele with
ISSN:0022-1899
1537-6591
1537-6613
DOI:10.1086/588710