Pregnancy in patients with myelodysplastic syndromes (MDS)

Abstract We report 6 pregnancies in 5 females with low-risk myelodysplastic syndromes (MDS) (median age at diagnosis 28 years, range 26–29) observed in the last 15 years. In 2 cases pregnancy was concomitant to the diagnosis of MDS, in the remaining 4 cases the intervals from diagnosis were 2, 3, 4...

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Bibliographic Details
Published in:Leukemia research 2008-10, Vol.32 (10), p.1605-1607
Main Authors: Volpicelli, P, Latagliata, R, Breccia, M, Carmosino, I, Stefanizzi, C, Napoleone, L, Vozella, F, Levi, A, Natalino, F, Alimena, G
Format: Article
Language:English
Subjects:
Adult
Animals
Delivery
Female
Hematology, Oncology and Palliative Medicine
Humans
MDS
Myelodysplastic Syndromes - diagnosis
Pregnancy
Pregnancy Complications, Hematologic - diagnosis
Pregnancy Outcome
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Summary:Abstract We report 6 pregnancies in 5 females with low-risk myelodysplastic syndromes (MDS) (median age at diagnosis 28 years, range 26–29) observed in the last 15 years. In 2 cases pregnancy was concomitant to the diagnosis of MDS, in the remaining 4 cases the intervals from diagnosis were 2, 3, 4 and 9 years, respectively. One patient had a foetal growth retardation corrected with steroid treatment while the remaining 5 pregnancies were uneventful. After a median time from delivery of 104 months (range 18–187) none of the patients developed acute myeloid leukemia (AML) and all are alive in stable disease. In conclusion, selected females with low-risk MDS could not be discouraged to have full term pregnancies.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2008.02.006