Successful Treatment of Chronic Decubitus Ulcer with 0.1% Dirhamnolipid Ointment

Background: Previous investigations of the biologic activities of dirhamnolipid α-L-rhamnopyranosyl-(1–2)α-L-rhamnopyranosyl-3-hydroxydecanoyl-3–hydroxydecanoic acid have demonstrated that it could be a novel therapeutic agent for wound healing and various immunologic and dermatologic conditions. Ob...

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Published in:Journal of cutaneous medicine and surgery 2008-05, Vol.12 (3), p.142-146
Main Authors: Piljac, Ante, Stipčević, Tamara, Piljac-Žegarac, Jasenka, Piljac, Goran
Format: Article
Language:English
Subjects:
Aged, 80 and over
Biological and medical sciences
Buttocks
Chronic Disease
Dermatology
Disease management
Female
Glycolipids - therapeutic use
Humans
Medical sciences
Ointments
Pressure Ulcer - drug therapy
Skin diseases
Skin involvement in other diseases. Miscellaneous. General aspects
Studies
Wound healing
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Summary:Background: Previous investigations of the biologic activities of dirhamnolipid α-L-rhamnopyranosyl-(1–2)α-L-rhamnopyranosyl-3-hydroxydecanoyl-3–hydroxydecanoic acid have demonstrated that it could be a novel therapeutic agent for wound healing and various immunologic and dermatologic conditions. Objective: The aim of this article is to report the successful treatment of a decubitus ulcer with dirhamnolipid. Methods: The patient was a 90-year-old woman who developed a decubitus ulcer on her right buttock. The patient was initially treated by a standard procedure using pressure reduction, wound management, surgical intervention, and nutrition. The open, full-thickness wound progressed to a size of 10 × 7 cm, with evidence of tissue deterioration. The draining ulcer reached a dimension of 1 × 1.5 × 3 cm. The 0.1% dirhamnolipid ointment was administered at regular intervals, three times daily, by applying a thin layer of ointment directly to the wound area. Photographs were taken at regular 5-day intervals. Results: The standard therapy gave no improvement. Subsequently, therapy with topical dirhamnolipid ointment resulted in a completely healed wound on day 48 of the treatment. Conclusion: This case demonstrates that application of dirhamnolipid resulted in the healing of a chronic decubitus ulcer in an elderly, debilitated patient and might be a useful therapy to improve healing of decubitus ulcers.
ISSN:1203-4754
1615-7109
DOI:10.2310/7750.2008.07052