NFAT Signaling: Choreographing the Social Lives of Cells

Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA. Nuclear import is opposed by kinases such as GSK3, thereby rendering transcription continuously responsive to receptor o...

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Bibliographic Details
Published in:Cell 2002-04, Vol.109 (2), p.S67-S79
Main Authors: Crabtree, Gerald R, Olson, Eric N
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Animals
Calcineurin - metabolism
Calcium Channels - metabolism
Calcium Signaling
Cardiovascular System - cytology
Cardiovascular System - growth & development
Cardiovascular System - metabolism
DNA-Binding Proteins - metabolism
Feedback, Physiological
Humans
Lymphocytes - cytology
Lymphocytes - immunology
Macromolecular Substances
Musculoskeletal Development
Musculoskeletal System - cytology
Musculoskeletal System - metabolism
NFATC Transcription Factors
Nuclear Proteins
Signal Transduction
Transcription Factors - metabolism
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Description
Summary:Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA. Nuclear import is opposed by kinases such as GSK3, thereby rendering transcription continuously responsive to receptor occupancy. Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell–cell interactions.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(02)00699-2