Statistical Analysis of the Relationship between Translation Initiation AUG Context and Gene Expression Level in Humans

The preference for the optimal nucleotide of the mammalian translation initiation AUG context [GCCGCC(A/G)CCaugG] is generally more pronounced in the highly expressed genes than in the transcription factor genes at the −9 through −1 positions in humans. The influence of amino acid preference on the...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2002-03, Vol.66 (3), p.667-669
Main Authors: MIYASAKA, Hitoshi, KANAI, Shozo, TANAKA, Satoshi, AKIYAMA, Hideo, HIRANO, Masahiko
Format: Article
Language:English
Subjects:
Amino Acids - chemistry
AUG context
Biological and medical sciences
consensus sequence
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - genetics
human
Humans
Molecular and cellular biology
Molecular genetics
natural selection
Peptide Chain Initiation, Translational - genetics
Protein Biosynthesis - genetics
Ribosomal Proteins - chemistry
Ribosomal Proteins - genetics
Transcription Factors
Transcription. Transcription factor. Splicing. Rna processing
translation initiation
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Summary:The preference for the optimal nucleotide of the mammalian translation initiation AUG context [GCCGCC(A/G)CCaugG] is generally more pronounced in the highly expressed genes than in the transcription factor genes at the −9 through −1 positions in humans. The influence of amino acid preference on the nucleotide choice at the +4 position was also examined.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.66.667