The effect of anaesthetic technique on postoperative nausea and vomiting after day-case gynaecological laparoscopy

Gynaecological surgery is of high emetogenic potential and both total intravenous anaesthesia (TIVA) and prophylactic antiemetic therapy may reduce the incidence of postoperative nausea and vomiting (PONV). We studied 144 patients scheduled for day-case gynaecological laparoscopy in a randomized tri...

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Bibliographic Details
Published in:Anaesthesia and intensive care 2002-04, Vol.30 (2), p.153-159
Main Authors: PAECH, M. J, LEE, B. H. S, EVANS, S. F
Format: Article
Language:English
Subjects:
Abdominal surgery. Urology. Gynecology. Obstetrics
Adult
Ambulatory Surgical Procedures
Anesthesia
Anesthesia depending on type of surgery
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Intravenous
Antiemetics - administration & dosage
Biological and medical sciences
Double-Blind Method
Female
Gynecologic Surgical Procedures
Humans
Indoles - administration & dosage
Laparoscopy
Medical sciences
Postoperative Nausea and Vomiting - prevention & control
Premedication
Propofol
Prospective Studies
Quinolizines - administration & dosage
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Summary:Gynaecological surgery is of high emetogenic potential and both total intravenous anaesthesia (TIVA) and prophylactic antiemetic therapy may reduce the incidence of postoperative nausea and vomiting (PONV). We studied 144 patients scheduled for day-case gynaecological laparoscopy in a randomized trial comparing balanced inhalational anaesthesia and prophylactic dolasetron (group I+D) with propofol TIVA and dolasetron (group T+D) or TIVA alone (group T). The primary outcome of "complete response" (no vomiting, no treatment for PONV) was not significantly different among groups (34%, 51%, 32%; groups I+D vs T+D vs T, P=0.12). During the first hour after surgery, group I+D had nausea of greater severity (P
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057X0203000205