Cannabinoid system and feeding regulation

There is increasing evidence to suggest that the cannabinoid system is a crucial mechanism in the regulation of feeding and metabolism. It is against this background that a cannabinoid antagonist, rimonabant, is about to come onto the market for the treatment of obesity. Moreover, in addition to wei...

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Bibliographic Details
Published in:Adicciones 2008-01, Vol.20 (2), p.171-183
Main Author: Arias Horcajadas, Francisco
Format: Article
Language:Spanish
Subjects:
Animals
Brain - physiology
Cannabinoid Receptor Modulators - antagonists & inhibitors
Cannabinoid Receptor Modulators - physiology
Eating - physiology
Feeding and Eating Disorders - etiology
Humans
Obesity - etiology
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Summary:There is increasing evidence to suggest that the cannabinoid system is a crucial mechanism in the regulation of feeding and metabolism. It is against this background that a cannabinoid antagonist, rimonabant, is about to come onto the market for the treatment of obesity. Moreover, in addition to weight-loss effect, this drug has a beneficial effect on the so-called metabolic syndrome, with changes in the lipid and glucidic metabolism not observed for other anti-obesity drugs currently available. We present a review of current knowledge in this field and data from our own studies: genetic studies of this system in eating disorders and in obesity and studies of localization of cannabinoid receptors at sites related to feeding. These studies support a state of cannabinoid hyperactivity in obesity; furthermore, such hyperactivity can constitute a prognostic factor.
ISSN:0214-4840
DOI:10.20882/adicciones.281