Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure

Background: Pyruvate increases myocardial performance in isolated myocardium and improves hemodynamics in patients with congestive heart failure. Aims: To investigate the influence of pyruvate on detailed parameters of systolic and diastolic left ventricular (LV) function. Methods and Results: In pa...

Full description

Saved in:
Bibliographic Details
Published in:European journal of heart failure 2004-03, Vol.6 (2), p.213-218
Main Authors: Hermann, Hans-Peter, Arp, Jordis, Pieske, Burkert, Kögler, Harald, Baron, Steffen, Janssen, Paul M.L., Hasenfuss, Gerd
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Pressure
Cardiotonic Agents - therapeutic use
Female
Heart failure
Heart Failure - drug therapy
Heart Rate
Hemodynamics
Humans
Inotropic agents
Male
Middle Aged
Pyruvate
Pyruvic Acid - therapeutic use
Sarcoplasmic reticulum
Stroke Volume
Treatment Outcome
Ventricular Function, Left - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Pyruvate increases myocardial performance in isolated myocardium and improves hemodynamics in patients with congestive heart failure. Aims: To investigate the influence of pyruvate on detailed parameters of systolic and diastolic left ventricular (LV) function. Methods and Results: In patients with heart failure due to dilated cardiomyopathy (LVEF 30±4%, n=9) pyruvate was infused intracoronarily. LV function was analysed before, during and after application of different pyruvate concentrations using a LV‐micromanometer catheter. LV volumes were determined using cine ventriculography. Pyruvate increased maximum rate of LV isovolumic pressure rise (Peak +dP/dt) from 802±106 to 1125±103 mmHg/s (P
ISSN:1388-9842
1879-0844
DOI:10.1016/j.ejheart.2003.10.001