Hypocretin-1 (orexin-A) levels in human lumbar CSF in different age groups: Infants to elderly persons

Recent CSF and postmortem brain hypocretin measurements in human narcolepsy suggest that hypocretin deficiency is involved in the pathophysiology of the disease. In this study, we measured CSF hypocretin-1 levels in various age ranges from infants to elder people to investigate the age-dependent cha...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2002-05, Vol.25 (3), p.337-339
Main Authors: KANBAYASHI, Takashi, YANO, Tamami, ISHIGURO, Hideaki, KAWANISHI, Kentoh, CHIBA, Shigeru, AIZAWA, Rika, SAWAISHI, Yukio, HIROTA, Kouichi, NISHINO, Seiji, SHIMIZU, Tetsuo
Format: Article
Language:English
Subjects:
Activity levels. Psychomotricity
Adult
Age Factors
Aged
Biological and medical sciences
Brain Chemistry
Carrier Proteins - analysis
Carrier Proteins - cerebrospinal fluid
Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges
Culture Techniques
Female
Fundamental and applied biological sciences. Psychology
Humans
Infant
Intracellular Signaling Peptides and Proteins
Male
Middle Aged
Narcolepsy - cerebrospinal fluid
Neuropeptides - analysis
Neuropeptides - cerebrospinal fluid
Neuropeptides - deficiency
Orexins
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Spinal Puncture
Vertebrates: nervous system and sense organs
Vigilance. Attention. Sleep
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Summary:Recent CSF and postmortem brain hypocretin measurements in human narcolepsy suggest that hypocretin deficiency is involved in the pathophysiology of the disease. In this study, we measured CSF hypocretin-1 levels in various age ranges from infants to elder people to investigate the age-dependent change of hypocretin concentrations. CSF hypocretin levels were compared by age groups and gender. ANOVA was used to examine the influences of these two parameters on CSF hypocretin levels. University-based sleep and biology laboratory. Two hundred seventy two patients were included in this study, with 157 males and 115 females (0-79 years old). CSF samples were obtained by lumber punctures with informed consents. Hypocretin-1 levels are not different in respect to gender or age, although our samples constitute a heterogeneous group with various disease conditions. CSF hypocretin-1 levels in infants under 4 months are similar to those in adults. Early maturation of hypocretin transmission is suggested. No age- or gender-dependent changes in CSF hypocretin is observed.
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/25.3.337