Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats

• Published in: The Journal of nutritional biochemistry 2008-07, Vol.19 (7), p.467-474
• Main Authors: Ameho, Clement K., Chen, C.-Y. Oliver, Smith, Donald, Sánchez-Moreno, Concepción, Milbury, Paul E., Blumberg, Jeffrey B.
• Format: Article
• Language: English
• Subjects: alpha-tocopherol; alpha-Tocopherol - blood; animal models; Animals; antioxidant activity; Antioxidants; Antioxidants - metabolism; Biological and medical sciences; blood serum; blood serum protein carbonyls; carbonyl compounds; chemical constituents of plants; Feeding. Feeding behavior; free radical scavengers; free radicals; Fundamental and applied biological sciences. Psychology; gamma-tocopherol; intestinal absorption; isorhamnetin; liver; Male; malondialdehyde; Metabolism; nutrient availability; nutrient-nutrient interactions; nutritional status; Oxidative Stress; oxygen; plant-based foods; pyruvate kinase; Pyruvate Kinase - blood; Quercetin; Quercetin - metabolism; Rats; reactive oxygen species; secondary metabolites; skeletal muscle; Vertebrates: anatomy and physiology, studies on body, several organs or systems; vitamin deficiencies; Vitamin E Deficiency - blood; Vitamin E Deficiency - metabolism; vitamin metabolism; vitamin supplements; α-Tocopherol
• ISSN: 0955-2863; 1873-4847
• DOI: 10.1016/j.jnutbio.2007.06.004

Dietary antioxidants interact in a dynamic fashion, including recycling and sparing one another, to decrease oxidative stress. Limited information is available regarding the interrelationships in vivo between quercetin and vitamin E. We investigated the antioxidant activity and metabolism of quercetin (Q) in 65 F-344 rats ( n=13 per group) randomly assigned to the following vitamin E (VE)-replete and -deficient diets: (a) VE replete (30 mg α-tocopherol acetate/kg diet) control ad libitum (C-AL), (b) VE replete pair fed (C-PF), (c) VE replete+5.0 g Q/kg diet (R-VE+5Q), (d) VE deplete (