Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend

Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly(ethylene-co-vinyl acetate) (PEVA), or from a 50:50 blend of the two. The fibers were electrospun from chloroform solutions cont...

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Bibliographic Details
Published in:Journal of controlled release 2002-05, Vol.81 (1), p.57-64
Main Authors: Kenawy, El-Refaie, Bowlin, Gary L., Mansfield, Kevin, Layman, John, Simpson, David G., Sanders, Elliot H., Wnek, Gary E.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacokinetics
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biomaterials
Biomedical polymers
Chemistry, Pharmaceutical
Controlled release
Drug Carriers - pharmacokinetics
Drug delivery
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
Elasticity
Electrospinning
General pharmacology
Lactic Acid - pharmacokinetics
Macromolecular Substances
Medical sciences
PEVA
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
PLA
Polyesters
Polymers - pharmacokinetics
Polyvinyls - pharmacokinetics
Static Electricity
Tetracycline - pharmacokinetics
Tetracycline hydrochloride
Viscosity
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Summary:Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly(ethylene-co-vinyl acetate) (PEVA), or from a 50:50 blend of the two. The fibers were electrospun from chloroform solutions containing a small amount of methanol to solubilize the drug. The release of the tetracycline hydrochloride from these new drug delivery systems was followed by UV–VIS spectroscopy. Release profiles from the electrospun mats were compared to a commercially available drug delivery system, Actisite ® (Alza Corporation, Palo Alto, CA), as well as to cast films of the various formulations.
ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(02)00041-X