Enantioselective Suzuki Reactions: Catalytic Asymmetric Synthesis of Compounds Containing Quaternary Carbon Centers

Prochiral ditriflates can act as substrates in asymmetric Suzuki couplings by using an enantioselective desymmetrization strategy. The products are obtained with selectivities up to 86 % ee and contain a quaternary carbon center and a synthetically useful vinyl triflate functionality (see scheme).

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2004-02, Vol.43 (10), p.1249-1251
Main Authors: Willis, Michael C., Powell, Luke H. W., Claverie, Christelle K., Watson, Simon J.
Format: Article
Language:English
Subjects:
asymmetric catalysis
cross-coupling
enantioselectivity
palladium
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Description
Summary:Prochiral ditriflates can act as substrates in asymmetric Suzuki couplings by using an enantioselective desymmetrization strategy. The products are obtained with selectivities up to 86 % ee and contain a quaternary carbon center and a synthetically useful vinyl triflate functionality (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200352648