Stimulatory and inhibitory effects of 5-HT(1A) receptors on adrenocorticotropic hormone and cortisol secretion in a teleost fish, the Arctic charr (Salvelinus alpinus)

The serotonin(1A) (5-HT(1A)) receptor agonist 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) was administrated to juvenile Arctic charr either by intraperitoneal (i.p.) injections or through a permanent i.p. implanted catheter. 8-OH-DPAT induced an elevation of plasma cortisol in non-stressed fi...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2002-05, Vol.324 (3), p.193-196
Main Authors: Höglund, Erik, Balm, Paul H M, Winberg, Svante
Format: Article
Language:English
Subjects:
8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - metabolism
Animals
Hydrocortisone - blood
Hydrocortisone - metabolism
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - metabolism
Neural Inhibition - drug effects
Neural Inhibition - physiology
Neural Pathways - drug effects
Neural Pathways - physiology
Neurons - drug effects
Neurons - metabolism
Pituitary-Adrenal System - drug effects
Pituitary-Adrenal System - metabolism
Receptors, Serotonin - drug effects
Receptors, Serotonin - metabolism
Receptors, Serotonin, 5-HT1
Serotonin - metabolism
Serotonin Receptor Agonists - pharmacology
Stress, Physiological - blood
Stress, Physiological - physiopathology
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
Trout - anatomy & histology
Trout - metabolism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The serotonin(1A) (5-HT(1A)) receptor agonist 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) was administrated to juvenile Arctic charr either by intraperitoneal (i.p.) injections or through a permanent i.p. implanted catheter. 8-OH-DPAT induced an elevation of plasma cortisol in non-stressed fish (receiving the drug through a permanent i.p. catheter), whereas 8-OH-DPAT had the opposite effect when administrated through a standard i.p. injection, dampening the rise in cortisol induced by handling and injection, an effect which was most pronounced at low doses of 8-OH-DPAT. In both cases, plasma levels of adrenocorticotropic hormone followed the same general pattern as plasma cortisol. The results suggests that 5-HT(1A) receptors are involved in the regulation of hypothalamic-pituitary-interrenal axis activity in Arctic charr, but the effect of 5-HT(1A) stimulation seems to vary depending on the state of the fish.
ISSN:0304-3940