Brain and other natriuretic peptides: molecular aspects

Natriuretic peptides have emerged as important candidates for development of diagnostic tools and therapeutic agents in cardiovascular disease. The family contains of three major peptides—ANP, BNP, CNP—that participate in cardiovascular and cardiorenal homeostasis. Each of these natriuretic peptides...

Full description

Saved in:
Bibliographic Details
Published in:European journal of heart failure 2004-03, Vol.6 (3), p.261-268
Main Authors: Vanderheyden, Marc, Bartunek, Jozef, Goethals, Marc
Format: Article
Language:English
Subjects:
Atrial Natriuretic Factor - physiology
Heart failure
Humans
Natriuretic Peptide, Brain - physiology
Natriuretic peptides
Natriuretic Peptides - physiology
Receptors, Atrial Natriuretic Factor - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Natriuretic peptides have emerged as important candidates for development of diagnostic tools and therapeutic agents in cardiovascular disease. The family contains of three major peptides—ANP, BNP, CNP—that participate in cardiovascular and cardiorenal homeostasis. Each of these natriuretic peptides binds differentially to specific receptors that signal through different mechanisms. They are cleared enzymatically by neutral endopeptidase as well as by receptor‐mediated endocytosis. Because of its fast induction and specific expression in overt heart failure, BNP seems the most promising natriuretic peptide. It is predominantly synthesized in the cardiac ventricles, released as pre‐proBNP and then enzymatically cleaved to BNP and the N‐terminal portion of BNP(NT‐proBNP). Blood measurements of BNP and NT‐proBNP have been shown to identify patients with LV dysfunction. This review focuses on the physiology of natriuretic peptides as a group and brain natriuretic peptide in more detail, its structure and regulation as well as its effects at the cellular level.
ISSN:1388-9842
1879-0844
DOI:10.1016/j.ejheart.2004.01.004