Frequency and enzyme activity of the butyrylcholinesterase K-variant in a Turkish population

Among variants of the butyrylcholinesterase gene ( BChE), the K-variant causing Ala539Thr substitution is the most common one associated with about one-third reduction in the enzyme activity. This study aimed to detect the frequency of the K-variant allele in a Turkish population sample and also to...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2004-02, Vol.59 (12), p.875-877
Main Authors: Babaoglu, Melih O, Ocal, Turgay, Bayar, Banu, Kayaalp, S Oguz, Bozkurt, Atila
Format: Article
Language:English
Subjects:
Adult
Alleles
Butyrylcholinesterase - blood
Butyrylcholinesterase - genetics
Butyrylcholinesterase - metabolism
Female
Genetics, Population
Genotype
Humans
Male
Pharmacogenetics
Turkey
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Summary:Among variants of the butyrylcholinesterase gene ( BChE), the K-variant causing Ala539Thr substitution is the most common one associated with about one-third reduction in the enzyme activity. This study aimed to detect the frequency of the K-variant allele in a Turkish population sample and also to evaluate how the plasma BChE activity was influenced by this variant. Patients administered for elective surgery ( n=77) were examined for the presence of the K allele. The enzyme activity was determined in plasma. The K-variant of BChE is a common allele with a frequency of 0.266 (CI(95%) 0.196-0.336) in our sample from a Turkish population. Mean enzyme activity in subjects homozygous for the K-variant was about 40% lower than other subjects. The frequency of the BChE K-variant was significantly higher in a Turkish population than those reported for other populations and it is associated with a diminished enzyme activity.
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-003-0716-x