Corticosteroid treatment in meconium aspiration syndrome: a solution for better outcome?

Corticosteroid treatment in severe meconium aspiration syndrome may afford, especially if started early, some improvement in oxygenation, lung function and pulmonary haemodynamics during the acute phase of the disorder. Still, the effects of corticosteroids on lung tissue perturbations and outcome o...

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Bibliographic Details
Published in:Acta Paediatrica 2004-01, Vol.93 (1), p.5-7
Main Author: Kääpä, P
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Animals
Corticosteroids
Humans
Infant
Infant, Newborn
inflammation
meconium aspiration syndrome
Meconium Aspiration Syndrome - complications
Meconium Aspiration Syndrome - drug therapy
Meconium Aspiration Syndrome - physiopathology
Swine
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Summary:Corticosteroid treatment in severe meconium aspiration syndrome may afford, especially if started early, some improvement in oxygenation, lung function and pulmonary haemodynamics during the acute phase of the disorder. Still, the effects of corticosteroids on lung tissue perturbations and outcome of diseased infants remain unclear. Conclusion: Further research is needed to determine the clinical significance and optimal timing and dosing of corticosteroid treatment in severe meconium aspiration syndrome.
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2004.tb00664.x